A hypothesized structure of gliadin.


Alpha-helices in regions II and IV
(regions II and IV made up of a repetitive sequence of glutamine residues).

Disulphide bonds

  1. = cys152
  2. = cys182
  3. = cys183
  4. = cys195
  5. = cys299
  6. = cys307

Region I (hydrophobic region)
Region III
Region V

A molecule of gliadin in solution spontaneously combines with other molecules through hydrogen bonding to form a UNIT. Formation of the unit causes the exposure of hydrophobic groups making it insoluble in water. These exposed hydrophobic groups interact with other units to form large aggregates.

©Georges-Louis Friedli 1996