model

model
A hypothesized structure of deamidated gliadin.

Legend:
Alpha-helices in regions II and IV
(regions II and IV made up of a repetitive sequence of glutamic acids).
Disulphide bonds

= cys152
= cys182
= cys183
= cys195
= cys299
= cys307

Region I (hydrophobic region)
Region III
Region V

Deamidation of the gliadin molecule changed the glutamine residues to glutamic acid residues which caused electrostatic repulsion between the molecules. The hydrogen bonding holding the molecules together in gliadin were replaced by electrostatic repulsion which caused deamidated gliadin to aggregate through hydrophobic interaction exposing carboxyl groups making the deamidated gliadins soluble in water.