INGREDIENTS
Cynara scolymus, Glycyrrhiza glabra, Taraxacum officinale, Carduus marianus, , Arctium lappa, Eleutherococcus senticosus, Gentiana lutea, Curcuma longa, Schisandra chinensis,
ACTION
The Liver Tonic was formulated to:
RESEARCH
Cynara scolymus, like Carduus marianus protects the liver against toxins and infection (Samochowiec, L et al. 1971).
In addition, it stimulated regeneration of liver cells (Maros, T. et al. 1966, 1968).
Schisandra chinensis was found to protect the liver against aflatoxin B1 and Cd toxicity (Ip, S.P. et al. 1996). It also stimulated liver regeneration after partial hepatectomy (Kubo, S. et al. 1992). During recent times, Schisandra has been found to be effective in viral and chemical induced hepatitis (Liu, G.T. 1989).
Silymarin's hepatoprotective effects are accomplished via several mechanisms including antioxidation, inhibition of lipid peroxidation, enhanced liver detoxification via inhibition of Phase I detoxification and enhanced glucuronidation, and protection of glutathione depletion (Monograph:Silybum marianum [MilkThistle], 1999).
Silybum marianum (milk thistle) has been shown to have clinical applications in the treatment of toxic hepatitis, fatty liver, cirrhosis, ischemic injury, radiation toxicity, and viral hepatitis via its antioxidative, anti-lipid peroxidative, antifibrotic, anti-inflammatory, immunomodulating, and liver regenerating effects. (Luper, S. 1998)
Curcumin is a natural phenolic compound found in the rhizomes of Curcuma longa and endowed with beneficial biological activities including antioxidant, anticarcinogenic and hepatoprotective effects (Romiti, N. et al. 1998)
REFERENCES
Ip, S.P., Mak, D.H., Li, P.C., Poon, M.K., Ko, K.M. (1996). Effect of a lignan-enriched extract of Schisandra chinensis on aflatoxin B1 and cadmium chloride-induced hepatotoxicity in rats. Pharmacol. Toxicol. 78(6):413-6
Kubo, S., Ohkura, Y., Mizoguchi, Y., Matsui-Yuasa, I., Otani, S., Morisawa, S., Kinoshita, H., Takeda, S., Aburada, M. and Hosoya, E. (1992). Effect of Gomisin A (TJN-101) on liver regeneration. Planta. Med. 58(6):489-92.
Liu, G.T. (1989). Pharmacological actions and clinical use of fructus schizandrae. Chin. Med. J. 102(10):740-9.
Luper, S. (1998). A review of plants used in the treatment of liver disease: part 1. Altern. Med. Rev. 3(6):410-21.
Maros, T., Racz, G., Katonai, B., Kovacs, V.V. (1966). Effects of Cynara Scolymus extracts on the regeneration of rat liver. 1. Arzneimittelforschung 16(2):127-9.
Maros, T., Seres-Sturm, L., Racz, G., Rettegi, C., Kovacs, V.V. and Hints, M. (1968). Effect of Cynara scolymus-extracts on the regeneration of rat liver. 2. Arzneimittelforschung 18(7);884-6.
Monograph:Silybum marianum (MilkThistle). Altern. Med. Rev. 1999 Aug;4(4):272-274
Romiti, N., Tongiani, R., Cervelli, F., Chieli, E. (1998). Effects of curcumin on P-glycoprotein in primary cultures of rat hepatocytes.
Life Sci. 62(25):2349-58.
Samochowiec, L. et al. (1971). The influence of 1,5-dicaffeoylquinic acid on Serum Lipids in the Experimentally Alcoholised Rat. Panminerve Medica. 13;87.
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